NCT04932343Unknown不适用
Comparison of Genomic and Transcriptomic Patterns Between the Circulating Tumor Cells and Metastatic Tumor Cells, and Their Specific Relevance to Circulating Tumor DNAs: Quest for Any Distinct or Complementary Roles of CTCs and ctDNAs to Understand the Metastasis in Advanced NSCLC
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- The gene expression and the cell population
研究概览
简要总结
This study aims to understand the metastasis in advanced NSCLC through comparing genomic and transcriptomic patterns between the circulating tumor cells and metastatic tumor cells by single cell sequencing analysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All subjects need to sign the informed consent form
- •All subjects have non-small cell lung cancer which suspected on chest CT or confirmed pathologically preoperatively
- •Treatment naïve advanced lung cancer (including extensive stage IIIb and stage IV)
- •Patients who were suitable to provide enough metastatic tumor tissue and blood (30ml) for the single cells sequencing
排除标准
- •Patients with previous history of lung cancer
- •Have been undergone chemotherapy or radiotherapy due to non-small call lung cancer
- •Have been diagnosed any type of cancer other than cancer of skin, thyroid, uterine cervix within 5 years before enrollment
结局指标
主要结局
The gene expression and the cell population
时间窗: 3 year
Methods for the single cell RNA sequencing and whole exome sequencing of the tumor cells With the tissue biopsied specimens, scRNAseq (by 10X Genomics platform) and whole exome seq will be carried out.
次要结局
未报告次要终点
研究者
Jhingook Kim, MD
Professor
Samsung Medical Center
研究点 (1)
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