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临床试验/NCT03538821
NCT03538821已完成不适用

The Effects of a Daily Intake of Protein From Cod Fillet and Cod Residual Material for 8 Weeks on Serum Lipids and Fatty Acids, Glucose Regulation and Inflammation Markers in Overweight or Obese Adults: A Randomized Controlled Trial.

University of Bergen2 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2017年1月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
100
试验地点
2
主要终点
Biomarkers related to lipid metabolism

研究概览

简要总结

A high intake of fish is associated with positive health effects, including prevention and treatment of chronic non-communicable diseases, such as cardiovascular diseases (CVDs) and type 2 diabetes. These health effects have traditionally been attributed to the omega-3 fatty acids in fatty fish, but recent studies have suggested that also fish proteins may improve biomarkers of metabolic disease. Intake of cod fillet have previously shown beneficial effects on blood lipids, glucose regulation and body composition in adults with overweight or obesity. Health effect of cod residual material from fillet production (i.e., head, backbone, skin, cutoffs and entrails) have so far not been investigated, but residuals from other fish species have shown promising effects on glucose regulation in rats. The main aim of the current study is to investigate the effects of protein from cod fillet and cod residuals on serum lipids, glucose regulation and inflammatory markers in healthy overweight or obese adults.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围
20 Years 至 55 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • BMI ≥ 27 kg/m2
  • Fasting blood glucose ≤7 mmol/L
  • Physically inactive
  • Percent body fat > 25 % for men and > 35 % for women

排除标准

  • Allergies towards fish, milk, egg, gluten
  • Tobacco use > 10 cigarettes (or snus) per day
  • Diseases affecting the heart, intestinal function, kidney function or insulin secretion
  • Medications targeting cholesterol -or glucose metabolism, hypertension
  • Use of dietary supplements
  • Pregnancy or lactation

结局指标

主要结局

Biomarkers related to lipid metabolism

时间窗: 8 weeks

Lipids will be measured in fasting serum samples

次要结局

  • Biomarkers related to glucose regulation(8 weeks)
  • Inflammatory markers(8 weeks)
  • Body composition(8 weeks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Oddrun Anita Gudbrandsen

Researcher, PhD

University of Bergen

研究点 (2)

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