The Cardiovascular Effects of Air Pollution: the Role of Nitric Oxide
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Forearm blood flow as measured by venous occlusion plethysmography during infusion of NOS inhibitors and vasodilators
研究概览
简要总结
Exposure to air pollution has been linked to increased cardiorespiratory morbidity and mortality. The exact component of air pollution that mediates this effect is unknown, but the link is strongest for fine combustion derived particulate matter derived from traffic sources. Recently, it has been demonstrated that inhalation of diesel exhaust impairs vascular vasomotor tone and endogenous fibrinolysis. The mechanism underlying these detrimental vascular is unclear, but is thought to be via oxidative stress and altered bioavailability of endogenous nitric oxide. In these studies we plan to elucidate the role of endogenous nitric oxide (NO) in the adverse vascular responses observed following exposure to diesel exhaust.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers
排除标准
- •Use of regular medication (except oral contraceptive pill)
- •Current smokers
- •Significant occupational exposure to air pollution
- •Intercurrent illness
研究组 & 干预措施
Diesel Exposure
1 hour exposure to dilute diesel exhaust at a concentration of 300 µg/m3 with intermittent exercise
干预措施: Forearm Vascular Study (Procedure)
Air Exposure
1 hour exposure to filtered air during intermittent exercise
干预措施: Forearm Vascular Study (Procedure)
结局指标
主要结局
Forearm blood flow as measured by venous occlusion plethysmography during infusion of NOS inhibitors and vasodilators
时间窗: 2-4 hours after exposure
次要结局
- Plasma concentrations of t-PA and PAI(After infusion of bradykinin during forearm study)
- Plasma nitrite concentrations(During forearm study)