Effects of Short-Term Resistance Training on Diaphragm Thickness, Hepatic Fat Density, and Quality of Life in Healthy Older Men: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Diaphragm Thickness
研究概览
简要总结
This randomized controlled trial investigated the effects of a four-week moderate-intensity resistance training program on diaphragm thickness, hepatic fat density, and health-related quality of life in healthy community-dwelling older men aged 60-75 years. Thirty participants were randomly assigned to a resistance training group or control group. Diaphragm thickness and hepatic attenuation were assessed using non-contrast computed tomography, and quality of life was evaluated using the SF-12 questionnaire. The primary outcome was change in diaphragm thickness. Secondary exploratory outcomes included hepatic fat density and SF-12 physical and mental health scores.
详细描述
Aging is associated with progressive decline in respiratory muscle morphology, metabolic health, and perceived quality of life. While resistance training is well established for peripheral muscle adaptation, its short-term effects on diaphragm morphology and hepatic tissue density remain insufficiently investigated.
This randomized controlled pre-test-post-test trial enrolled 30 healthy men aged 60-75 years. Participants were randomly allocated (1:1) to:
Resistance Training Group (RT) Control Group (CON) The RT group completed a supervised moderate-intensity resistance training program three times per week for four weeks (30-40 minutes/session, RPE 12-15). The control group maintained usual daily activities.
Primary Outcome:
Change in diaphragm thickness (mm) assessed by non-contrast CT
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
盲法说明
Participants were not blinded to group allocation because of the nature of the exercise intervention. The personnel delivering the intervention were also aware of group allocation. Outcome assessors, including the radiologist responsible for CT-based diaphragm thickness assessment, and the statistician were blinded to group allocation.
入排标准
- 年龄范围
- 60 Years 至 75 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age 60-75 years
- •Community-dwelling and functionally independent
- •No structured exercise program in past 6 months
- •No musculoskeletal injury in past 6 months
- •Ability to provide written informed consent
- •Stable neuropsychological status
排除标准
- •Chronic liver disease
- •Uncontrolled cardiovascular or pulmonary disease
- •Recent respiratory infection
- •Use of medications affecting muscle or liver metabolism (e.g., systemic corticosteroids, anabolic agents, hepatotoxic drugs)
- •Participation in structured exercise or respiratory training within past 6 months
- •Unstable thyroid hormone replacement therapy
研究组 & 干预措施
Resistance Training Group (RT)
Participants performed supervised resistance training three times per week for four weeks. Each session lasted 30-40 minutes and included:
Lower body exercises (sit-to-stand, step-ups, glute bridge) Upper body exercises (wall push-ups, resistance band row, biceps curl) Core exercises Breathing exercises (diaphragmatic breathing, pursed-lip breathing) Warm-up protocol (10 minutes dynamic mobility) Intensity: Borg RPE 12-15 Rest interval: 60 seconds between sets
干预措施: Resistance Training Group (RT) (Behavioral)
Resistance Training Group (RT)
Participants performed supervised resistance training three times per week for four weeks. Each session lasted 30-40 minutes and included:
Lower body exercises (sit-to-stand, step-ups, glute bridge) Upper body exercises (wall push-ups, resistance band row, biceps curl) Core exercises Breathing exercises (diaphragmatic breathing, pursed-lip breathing) Warm-up protocol (10 minutes dynamic mobility) Intensity: Borg RPE 12-15 Rest interval: 60 seconds between sets
干预措施: Control (Other)
CONTROL
Participants maintained their usual daily routines without structured exercise intervention.
结局指标
主要结局
Diaphragm Thickness
时间窗: 4 weeks
Diaphragm thickness measured in millimeters using non-contrast computed tomography at full inspiration.
次要结局
- Hepatic Fat Density(4 weeks)
- SF-12 Physical Health Score(4 weeks)
- SF-12 Mental Health Score(4 weeks)
研究者
Coşkun YILMAZ
ASSOC. PROF.
Gümüşhane Universıty