ISRCTN07329370
已完成
4 期
An open-label study of intra-articular steroid injection in the management of symptomatic knee osteoarthritis
Salford Royal NHS Foundation Trust (UK)0 个研究点目标入组 120 人2010年5月21日
概览
- 阶段
- 4 期
- 干预措施
- 未指定
- 疾病 / 适应症
- Topic: Musculoskeletal, Primary Care Research Network for England
- 发起方
- Salford Royal NHS Foundation Trust (UK)
- 入组人数
- 120
- 状态
- 已完成
- 最后更新
- 8年前
概览
简要总结
暂无简介。
研究者
入排标准
入选标准
- •1\. Age 40 \- 79 years
- •2\. Male or female
- •3\. Ambulatory (not wheelchair bound)
- •4\. Able and willing to attend or comply with intervention and follow up
- •5\. Within the last 24 months:
- •5\.1\. Radiological (X\-ray) evidence of grade 2 or more OA
- •5\.2\. Evidence of significant OA on MRI scan
- •5\.3\. Documented evidence of at least grade 2 arthritis on arthroscopy
- •6\. Moderate knee pain lasting 48 hours in the past 2 weeks
- •7\. Presence of clinically apparent knee effusion
排除标准
- •1\. Secondary OA \- septic arthritis, gout
- •2\. History of inflammatory arthritis
- •3\. Previous intra\-articular Ostenil or steroid injection within 6 months
- •4\. Previous knee surgery (including cartilage surgery) or arthroscopy within 6 months
- •5\. Inability to understand the procedures
- •6\. Pregnancy
- •7\. Chronic kidney disease with estimated glomerular filtration rate (eGFR) greater than or equal to 44 ml/min
- •8\. Concurrent life threatening illness
- •9\. Implants which prohibit safe use of MRI scan including cochlear implants/metal objects in the body including joint prosthesis, cardiac or neural pacemakers, hydrocephalus shunts, intrauterine device or coil
- •10\. Known hypersensitivity to Depomedrone or any components of its excipients
结局指标
主要结局
未指定
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