Aortic Stenosis * Identification of high-risk valve pathology using STRESS physiology (AoS-STRESS) - AoS-STRESS

Catharina-ziekenhuis0 个研究点目标入组 50 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

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•-Age * 18 years.
•-Undergoing TAVI or balloon valvuloplasty for standard clinical indications/undergoing coronary catheterization and have had an echo with a moderate aortic stenosis in the last 3 months
•-Ability to understand and the willingness to sign a written informed consent.

•-Unrevascularized and severe coronary artery disease (for example a 90% diameter stenosis or FFR<0.7 in the proximal left anterior descending artery) that in the opinion of the primary TAVI/BAV operator would produce significant ischemia during dobutamine infusion.
•-Significant aortic regurgitation, mitral valve disease, tricuspid regurgitation, or intracardiac shunt that would invalidate thermodilution cardiac output or the interpretation of transvalvular flow across the aortic valve.
•-Co-existing hypertrophic cardiomyopathy.
•-Atrial fibrillation or tachycardia with rapid ventricular response, a history of significant ventricular tachycardia or fibrillation, or an implanted cardiac defibrillator whose treatment thresholds would be reached during dobutamine infusion.
•-Known hypersensitive response to dobutamine.
•-Recent (within 3 weeks prior to cardiac catheterization) ST-segment elevation myocardial infarction (STEMI) in any arterial distribution.

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