Translational Initiative to Map Epigenetics in Sleep
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 10,000
- 主要终点
- Effect of being "out of phase" with chronotype on biological age
研究概览
简要总结
The primary aim of TIME-ZZZ is to explore the relationship between chronotype, incidence of depression and biological age, and whether individuals working "out-of-phase" with their chronotype are more likely to exhibit signs of depression and accelerated biological aging.
详细描述
Understanding the relationship between chronotype, depression, and biological age is important in the field of sleep research and mental health. Sleep patterns and their alignment with an individual's internal body clock, or chronotype, have been increasingly recognized as influential factors in various aspects of well-being, including mental health and overall physiological aging. By conducting a study that investigates the potential correlation between chronotype, incidence of depression, and biological age, along with the impact of working "out-of-phase" with one's chronotype, the investigators can shed light on crucial aspects of sleep, mental health, and their interplay with biological aging.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Has taken an INDEX test within the last 3 months
- •Has registered at least 1 INDEX kit via the Elysium Health website
- •Able and willing to provide digital consent to the RSCF, and the TIME-ZZZ Research Subject Consent Form
排除标准
- •Consent to participate not given
结局指标
主要结局
Effect of being "out of phase" with chronotype on biological age
时间窗: At baseline
Determine whether individuals working "out-of-phase" with their chronotype (from TIME-ZZZ survey responses) exhibit higher rates of biological aging compared to those working within their chronotype
次要结局
- Identification of DNA methylation markers associated with chronotype(At baseline)
- Identification of DNA methylation markers associated with depression(At baseline)
- Effect of Chronotype Alignment and Depression Risk in Relation to Rate of Aging(At baseline)