Metabolic Profile in Women of Different Body Composition With Polycystic Ovary Syndrome
试验速览
- 阶段
- 不适用
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Metabolic profile
研究概览
简要总结
Metabolic profile in women of different body composition with polycystic ovary syndrome.
详细描述
Will be performed case-control study with women with Polycystic Ovary Syndrome, according to the Rotterdam criteria and body mass index between 18 to 29.9. The control group will consist of women without Polycystic Ovary Syndrome, with a body mass index of 18 to 29.9 and no other comorbidities. In both groups collect anthropometric data such as age, weight, height, waist circumference and blood pressure. Exams will be requested: metabolic profile (total cholesterol (mg/dL) and fractions, triglycerides (mg/dL), blood count, liver function (U/L) and classical glycemic index (mg/dL); hormonal profile - insulin (uIU/ml), luteinizing hormone (IU/L), follicle stimulating hormone (IU/L), thyreostimulating hormone (uIU/ML), total and free testosterone (ng/ml), 17-hydroxyprogesterone (ng/ml), dehydroepiandrosterone (ng/ml), prolactin (ug/ml). Body composition (BMI) will be performed by absorption technique of two low energy beams emitted by X-ray - full body densitometry (DEXA). Expected result: To evaluate visceral fat and truncal of patients with diagnosis of Polycystic Ovary Syndrome without obesity.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 12 Years 至 39 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Polycystic Ovary Syndrome , body mass index of 18 to 29.9, without contraceptive use.
排除标准
- •Hypothyroidism, hyperprolactinaemia (defined as serum prolactin levels greater than 25 ng/mL)
- •Cushing's syndrome
- •Nonclassical congenital adrenal hyperplasia (defined as serum 17-hydroxyprogesterone levels greater than 1.2 and 5.2 ng/mL in the follicular and luteal phase, respectively) and current or previous (within the last three months) use of oral contraceptives and other hormonal
- •Antidiabetic and antiobesity drugs.
结局指标
主要结局
Metabolic profile
时间窗: 12 months
total cholesterol (mg/dL) and fractions, triglycerides (mg/dL) will estimate
次要结局
- Classical glycemic index(12 months)
- Total and free testosterone(12 months)
- Follicle stimulating hormone(12 months)
- 17-hydroxyprogesterone(12 months)
- Liver function(12 months)
- Hormonal profile - insulin(12 months)
- Prolactin(12 months)
- luteinizing hormone(12 months)
- thyreostimulating hormone(12 months)
- Dehydroepiandrosterone(12 months)
- DEXA(12 months)
研究者
Carolina Furtado Macruz
Doctor
Irmandade da Santa Casa de Misericordia de Sao Paulo