Impact of Neohepatic Albumin-Bilirubin Scores on Renal Outcomes Following Living-donor Liver Transplantation: Propensity Score Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 3,422
- 试验地点
- 1
- 主要终点
- acute kidney injury
研究概览
简要总结
This study investigates the association between post-reperfusion (neohepatic) ALBI scores and post-LT renal outcomes in living-donor LT (LDLT) recipients.
详细描述
Acute kidney injury (AKI) after liver transplantation (LT) significantly affects patient and graft outcomes. The Albumin-Bilirubin (ALBI) score, an objective and sensitive index of liver function, has potential applicability in predicting outcomes following LT. This study investigates the association between post-reperfusion (neohepatic) ALBI scores and post-LT renal outcomes in living-donor LT (LDLT) recipients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •living donor liver transplantation recipients (≥18 years)
排除标准
- •preoperative serum creatinine (sCr) > 1.4 mg/dL, diagnosed CKD or hepatorenal syndrome (HRS), or hemodialysis at baseline
结局指标
主要结局
acute kidney injury
时间窗: within 7 days after surgery
determined by change in sCr according to the Kidney Disease: Improving Global Outcomes (KDIGO) definition (increase in sCr of ≥26.5 mmol litre-1 within 48h or ≥1.5 times baseline within 7 days after surgery
次要结局
- chronic kidney injury(within 1 year after surgery)
- graft failure(the graft failure at overall period (calculated from the date of surgery to the last follow-up) from the date of surgery (up to 10 years)])
研究者
Jun-Gol Song
Professor
Asan Medical Center