ACTRN12610000650099已完成3 期
A randomised, double-blind, placebo-controlled trial to assess the effect of phosphate reduction with lanthanum carbonate on arterial compliance and vascular calcification in patients with chronic kidney disease stages 3b-4.
Australasian Kidney Trials Network (University of Qld)0 个研究点目标入组 278 人开始时间: 2010年8月10日最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 278
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •Patients with Chronic Kidney Disease (CKD) Stages 3b-4 (eGFR between 15-44ml/ min/1.73m2) 2. Serum phosphate level greater than 1.00mmol/L on at least 1 occasion over the previous 6 months.
排除标准
- •1. Patients with a history of psychological illness or condition which interferes with their ability to understand or comply with the requirements of the study
- •2. Renal transplantation
- •3. Recent (within 1 month) hospitalisation or cardiovascular event
- •4. Pregnancy or breast feeding
- •5. Medical conditions that impact on phosphate metabolism (apart from CKD), eg. primary hyperparathyroidism or hypoparathyroidism; previous subtotal parathyroidectomy; gastrointestinal malabsorption disorders such as Crohn’s disease, ulcerative colitis, coeliac disease or severe liver dysfunction
- •6. Malnutrition, defined as serum albumin <30g/L
- •7. Presence of atrial fibrillation
- •8. Inability to obtain a pulse wave velocity
研究者
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