Time Lag for Oocyte Denudation:Is it a Better Choice for ICSI Outcome?!
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Day 5, good quality blastocyst
研究概览
简要总结
This study aiming to investigate if difference in the timing of cumulus removal post retrieval would have any critical impact on fertilization and embryonic development.
详细描述
Patients under 37 year old who were treated with controlled ovarian stimulation for ICSI were randomly divided into 2 groups; Group A: Oocytes were denudated immediately after oocyte retrieval , Group B: Oocytes were denudated 2 hours after retrieval and both groups were microinjected at 4 hours from ovum pickup. Microinjection was performed on all matured oocytes only and they were cultured to blastocyst stage.The rates of maturation, fertilization, good quality blastulation, chemical pregnancy and clinical pregnancy were analysed and compared between the two groups.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 24 Years 至 37 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women 24-37 years old
- •With good ovarian reserve
- •Induction using Long agonist protocol
- •unexplained infertility
排除标准
- •severe male factor
- •Testicular samples for ICSI
- •poor ovarian reserve
- •no of oocytes collected less than 4
结局指标
主要结局
Day 5, good quality blastocyst
时间窗: 120 hour post ovum pickup
Assessment were done according to gardener classification
次要结局
- clinical pregnancy(6 weeks from the last normal menstrual period)
研究者
Ahmed Saad
Assistant professor of Obstetrics & Gynecology
Benha University