Timing of COC Denudation and Embryo Quality: A Prospective Randomised Sibling-Oocyte Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Embryo utilization rate
研究概览
简要总结
The relation between the timing of COC denudation and oocyte /embryo quality is controversial. The aim of this study is to examine whether timing of denudation of sibling oocytes has any effect on embryo quality.
详细描述
Retrieved sibling cumulus-oocyte complexes (COCs) will be randomly divided into two groups, in the first group denudation will be in 30 minutes after oocyte retrieval, in second group denudation will take place after 2 hours of incubation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •COH with GnRH antagonist cycle
- •5 or more oocytes collected
排除标准
- •Fewer than 4 oocytes after retrieval
- •Previous history of total fertilization failure or oocyte maturation arrest
- •Male partner requiring surgical sperm retrieval (MESA or TESA).
结局指标
主要结局
Embryo utilization rate
时间窗: 1 week after microinjection
Embryo utilization rate is defined as the number of embryos utilized (transferred or cryopreserved) per number of 2PN zygotes.
Number of good quality cleavage embryos
时间窗: 3 days after microinjection
Quality of embryos will be assessed morphologically on day 3
次要结局
- Cleavage rate(2 days after microinjection)
- Fertilization rate(16-18 hour after microinjection)
- Blastulation rate(1 week after microinjection)
研究者
Elif Esra Uyar
Medical Doctor
Acıbadem Atunizade Hospital