Time Lag for Oocyte Denudation: A Better Choice for ICSI Outcome?!
- Conditions
- Infertility, Female
- Registration Number
- NCT04185623
- Lead Sponsor
- Ahmed Saad
- Brief Summary
This study aiming to investigate if difference in the timing of cumulus removal post retrieval would have any critical impact on fertilization and embryonic development.
- Detailed Description
Patients under 37 year old who were treated with controlled ovarian stimulation for ICSI were randomly divided into 2 groups; Group A: Oocytes were denudated immediately after oocyte retrieval , Group B: Oocytes were denudated 2 hours after retrieval and both groups were microinjected at 4 hours from ovum pickup. Microinjection was performed on all matured oocytes only and they were cultured to blastocyst stage.The rates of maturation, fertilization, good quality blastulation, chemical pregnancy and clinical pregnancy were analysed and compared between the two groups.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 300
- Women 24-37 years old
- With good ovarian reserve
- Induction using Long agonist protocol
- unexplained infertility
- severe male factor
- Testicular samples for ICSI
- poor ovarian reserve
- no of oocytes collected less than 4
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Day 5, good quality blastocyst 120 hour post ovum pickup Assessment were done according to gardener classification
- Secondary Outcome Measures
Name Time Method clinical pregnancy 6 weeks from the last normal menstrual period Assessment was done by observation of a gestational sac at 6 wks
Trial Locations
- Locations (1)
Hawaa Fertility Center
🇪🇬Banhā, Qalyubiya, Egypt
Hawaa Fertility Center🇪🇬Banhā, Qalyubiya, Egypt