The Neural Correlates of the " Self " in Altered States of Consciousness
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Reaction time (minutes)
研究概览
简要总结
Despite the increasing popularity of mindfulness meditation and hypnosis in healthcare and in the general community the underlying neurobiological mechanisms are unclear. The change in the relationship between the self and the conscious experience that they bring about may be crucial. This study aims to identify the neural correlates of self-consciousness in meta-awareness and absorption - using functional Magnetic Resonance Imaging (fMRI) in healthy participants combined with detailed first-person experiential accounts and behavioural tasks. This study will provide important clues about the widely reported effects of mindfulness meditation and hypnosis and shed light on the neural correlates of the conscious experience of self.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •aged 18-70
- •Body mass index between 18.5 and 30
- •Covered by health insurance
- •motivated to participate
- •signed informed consent
- •normal or corrected-to-normal eyesight
- •sufficient command of French to be able to follow the instructions
排除标准
- •history of neurological or psychiatric conditions
- •chronic pain or another medical condition altering pain perception
- •use of medication that affects the central nervous system
- •use of opioids or antidepressant medication
- •severe auditory loss
- •consumption of alcohol or intoxicants on the day of the experiments and the day preceding the experiments
- •pregnancy, breastfeeding or having given birth <6months ago
- •any contra-indication to Magnetic Resonance Imaging (metal implants or foreign bodies), agitation, claustrophobia
研究组 & 干预措施
Group 1
three instructions will be given to each participant: "control", "meditation", "hypnosis". The order of "meditation" and "hypnosis" will be randomized amongst two groups to avoid order effects.
干预措施: "control", "meditation", "hypnosis". (Behavioral)
Group 2
three instructions will be given to each participant: "control", "meditation", "hypnosis". The order of "meditation" and "hypnosis" will be randomized amongst two groups to avoid order effects.
干预措施: "control", "meditation", "hypnosis". (Behavioral)
结局指标
主要结局
Reaction time (minutes)
时间窗: at day 1
reaction times during behavioural tasks.
Brain activation with IRM
时间窗: At day 3
Activation of different brain areas, as measured with functional Magnetic Resonance
次要结局
- Scores during behavioural tasks(at day 3)
- salivary volume (millimeter)(at day 1)
- personality trait with questionnaires(at day 2)
- Scores during behavioural tasks(at day 1)