Evaluation of Pentraxin3 as an Early Marker in the Diagnosis of Ventilator-associated Pneumonia

Ventilator associated pneumonia (VAP) is a type of hospital-acquired pneumonia that occurs more than 48h after endotracheal intubation. This can be further classified into early onset (within the first 96 hours of mechanical ventilation (MV) and late onset (more than 96 hours after the initiation of MV), which is more commonly attributable to multidrug-resistant pathogens Ventilator associated pneumonia is common in critical care patients and is responsible for around half of all antibiotics given to patients in intensive care units. International Nosocomial Infection Control Consortium suggest that the overall rate of VAP is 13.6 per 1000 ventilator days. However, the individual rate varies according to patient group, risk factors and hospital setting. The average time taken to develop VAP from the initiation of MV is around 5 to 7 days, with a mortality rate quoted as between 24% and 76%.

The key to the development of VAP is the presence of an endotracheal tube (EET) or tracheostomy, both of which interfere with the normal anatomy and physiology of respiratory tract, specifically the functional mechanisms involved in clearing secretion (cough and mucociliary action).

Intubated patients have a reduced level of consciousness that impairs voluntary clearance of secretions, which may then pool in the oropharynx. This leads to the macro aspiration and micro aspiration of contaminated oropharyngeal secretions that are rich in harmful pathogens. Normal oral flora starts to proliferate and are able to pass along the tracheal tube, forming an antibiotic-resistant biofilm which eventually reaches the lower airways.

Critically unwell patients exhibit an impaired ability to mount an immune response to these pathogens, leading to the development of a pneumonia.

Early-onset VAP, occurring within the first four days of MV, is usually caused by antibiotic-sensitive community-acquired bacteria such as Hemophilus and Streptococcus. VAP developing more than 5 days after initiation of MV is usually caused by multidrug-resistant bacteria such as Pseudomonas aeruginosa.