Neuroimage Genome Study of Neuroplasticity Associated With Microgravity
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- Brain structure - Morphology
研究概览
简要总结
This clinical trial investigates the neuroplasticity and cognitive status changes of the human brain in microgravity. To explore the relationship between cognitive status changes and brain functional activities, gray matter and white matter changes under microgravity exposure, screen and identify representative image markers, so as to provide decision-making information for the cognitive status changes of relevant personnel under microgravity environment.
详细描述
MRI has the advantage of non-invasive and non-radiation, and imaging the human brain after exposure to microgravity can reveal the neuroplastic changes in the astronaut's brain and discover the characteristics of functional activities behind it. The purpose of this study is to explore the image features and cognitive state related information related to the changes of human brain neuroplasticity under microgravity environment, and to identify the related image markers. At the same time, the pathophysiological mechanism is preliminarily discussed in this study. This study is helpful for us to explore the sensitivity of different brain structures and brain functions to space microgravity environment, so as to further understand the role and influence of space missions on brain health.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Male aged 18-60 years
- •No mental or other neurological disorders, no history of drug or alcohol abuse
- •Generally in good condition, no clear major physical diseases, no hearing disorders
- •No metal foreign bodies in the body, no contraindications to MRI scanning
- •No claustrophobia
- •Agree to participate in the clinical study and sign the informed consent
排除标准
- •There are electronic implants or metal foreign bodies, such as cardiac pacemakers
- •People with aneurysm surgery and intracranial aneurysm clip
- •People who have had heart surgery and used artificial heart valves
- •Having family planning
- •Uncontrolled epilepsy or mental illness, can't cooperate with MRI examination
- •Severe claustrophobia, can't cooperate with magnetic resonance examination
- •Other circumstances that the clinical trial personnel consider inappropriate to participate in the study
结局指标
主要结局
Brain structure - Morphology
时间窗: 60 days after the Head-Down tilt Bed Rest test
Based on 3D-T1WI, the changes of brain structure before and after the Head-Down tilt Bed Rest test were compared.
Local brain functional activity
时间窗: 60 days after the Head-Down tilt Bed Rest test
Based on resting-state functional MRI images, the changes of local brain functional activity before and after the Head-Down tilt Bed Rest test were compared.
Brain functional connectivity
时间窗: 60 days after the Head-Down tilt Bed Rest test
Based on resting-state functional MRI images, the changes of brain functional connectivity before and after the Head-Down tilt Bed Rest test were compared.
Brain fiber bundle and brain Diffusion index
时间窗: 60 days after the Head-Down tilt Bed Rest test
Based on diffusion tensor imaging, the changes of brain fiber bundle and brain diffusion index before and after the Head-Down tilt Bed Rest test were compared.
Brain blood flow
时间窗: 60 days after the Head-Down tilt Bed Rest test
Based on arterial spin labeling, the changes of brain blood flow before and after the Head-Down tilt Bed Rest test were compared.
Imaging indexes and clinical scale scores
时间窗: 60 days after the Head-Down tilt Bed Rest test
Based on the changes of relevant imaging indexes and the changes of relevant clinical scale scores, explore the correlation between the changes of relevant imaging indexes and relevant clinical scales scores.
次要结局
未报告次要终点
研究者
Xin Lou
Director and Clinical Professor
Chinese PLA General Hospital