Morbidity and Mortality of Hepatitis E Virus Infections in Belgium 2010-2018
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 280
- 主要终点
- HEV viral factors associated with morbidity and mortality
研究概览
简要总结
Hepatitis E Virus (HEV) infections are emerging in the Western world with a predominance of HEV genotype (gt) 3. Except for age older than 50 years, male gender, chronic liver disease and immunosuppressed status, no correlators with clinical outcomes have been identified so far. With this study, we want to examine viral factors associated with the morbidity and mortality of HEV infections in Belgium as well as find correlators with clinical outcomes.
详细描述
- Study objectives
1.1. Primary objectives:
To examine viral factors, such as gt, subtype and viral load, associated with the morbidity and mortality of HEV infections in Belgium.
1.2. Secondary objectives:
- To describe host factors associated with the morbidity and mortality of HEV infections in Belgium.
- To find independent host and/or viral factors that are associated with the morbidity and mortality of HEV infections in Belgium.
- Investigational plan
2.1. General study design
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •HEV RNA positive AND/OR HEV immunoglobulin (Ig)M positive
- •Lab confirmation of the HEV infection performed at Sciensano
- •All ages will be included
- •Referring hospital in Belgium
排除标准
- •No confirmation of HEV serology AND/OR polymerase chain reaction (PCR) performed at Sciensano
- •Cases not diagnosed in Belgium
- •Cases without clinical outcome data
结局指标
主要结局
HEV viral factors associated with morbidity and mortality
时间窗: observation period 2010-2018
Viral factors, such as genotype, subtype and viral load, associated with the morbidity and mortality of HEV infections in Belgium
次要结局
- Host factors associated with the morbidity and mortality of HEV infections in Belgium.(observation period 2010-2018)
研究者
Thomas Vanwolleghem
Prof. Dr.
University Hospital, Antwerp