Analysis of the Distribution of Adrenal Steroids in Blood and Urine Measured by Mass Spectrometry Coupled to Liquid Chromatography in a Control Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- difference of the distribution of blood steroid values in a population control group
研究概览
简要总结
This is a biomedical research study on the determination of adrenal steroids. It has been proposed in recent years as a tool for the diagnostic orientation of an adrenal pathology. The main objective is to analyze the distribution of blood and urinary adrenal steroid values in a population of 60 controls. The secondary objective is to establish reference values for each of these parameters, if their distribution permits, and to study the possible link between the blood pressure level, the orthostatism state, the potassium level and these adrenal steroids.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Negative blood pregnancy test
- •Normosalt diet
- •Men and women ≥ 18 years
- •Being able and willing to give written informed consent
排除标准
- •Personal history of diabetes, high blood pressure, adrenal pathologies.
- •Family history of adrenal pathologies.
- •Taking of the following drugs:
- •Antihypertensives drugs: ACE inhibitor, Angiotensin II receptor, beta-blocker, thiazide diuretic, loop diuretic, anti-aldosterone, dihydropyridine-type calcium antagonist.
- •Hormone replacement therapy, cyproterone acetate
- •NSAID (except occasional intake), corticosteroid
- •Antidepressant: serotonin reuptake inhibitor (paroxetine, fluoxetine, sertraline, citalopram)
- •Contraception or estrogen / progestin treatment (progestins only allowed)
- •Not be able to keep standing position.
结局指标
主要结局
difference of the distribution of blood steroid values in a population control group
时间窗: At baseline
The value will be measured by mass spectrometry coupled with liquid chromatography (HPLC-MS) and 16 global parameters will be analyses (B, 18-OH B, DOC, 18-OH DOC, S, F, 18-OH F, 17-OH progesterone, 21-desoxycortisol, delta 4 androstenedione, 17OHpregnenolone, aldosterone, SDHA, E, testosterone, estradiol
difference of the distribution of urinary steroid values in a population control group
时间窗: At baseline
The value will be measured by mass spectrometry coupled with liquid chromatography (HPLC-MS) and 6 global parameters will be analyses (E, F, THF, aTHF, THE, aldosterone)
次要结局
- Blood pressure taken while sitting, lying or standing(At baseline)
- blood concentration of kaliemia(at baseline)