Urinary Albumin Excretion in Women With Polycyclic Ovary Syndrome and it's Relation to Cardiovascular Risk Factors
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 主要终点
- Number of patients with hyperinsulinemia (uIU/ml)
研究概览
简要总结
PCO patients will be assessed clinically,urine & blood samples will be tested. Systolic & diastolic blood pressure, serum glucose & insulin levels, lipid profile, C-reactive protein, complete hormonal profile, and Urinary albumin excretion will be measured.
详细描述
PCO patients with 2 of 3 criteria: oligo- or anovulation ; hyperandrogenism &polycystic ovaries. Exclusion criteria: pregnancy, diabetes, hypertension , adrenal & thyroid dysfunction.
Blood samples after overnight fast (8hrs) at day 2 or 3 of menstrual cycle. Serum concentration of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, total testosterone & sex hormone binding globulin, serum 17-hydroxy (OH) progesterone & dehydroepiandrosterone sulfate will be measured.
Oral glucose tolerance test & plasma insulin levels will be measured. Total cholesterol, triglycerides, high& low density lipoproteins. Urinary albumin will be measured& all the data will be analysed.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •PCO patients
排除标准
- •pregnancy
- •hypertension
- •adrenal dysfunction
- •thyroid dysfunction
结局指标
主要结局
Number of patients with hyperinsulinemia (uIU/ml)
时间窗: 3 months
Number of patients with hyperlipidemia (mg/dl).
时间窗: 3 months
Number of patients with albuminuria(ug/ml)
时间窗: 3 months
次要结局
未报告次要终点
研究者
suzy abdelaziz Abdelhamid
lecturer of Obgyn
Kasr El Aini Hospital