A Study Utilising Tissue From Deceased Organ Donors to Investigate Regenerative Cellular Therapies and Related Physiological and Developmental Processes
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Number of donors from which induced Pluripotent Stem Cells were generated
研究概览
简要总结
This study aims to use tissue from deceased organ donors to investigate organ physiology, developmental biology, as well as the development of future regenerative cellular therapies. It will investigate function and immune response to stem cells as well as their generation from adult cells and generation of induced pluripotent stem cells (iPSCs).
详细描述
The purpose of this study is to use tissue from deceased organ donors to address questions that are of importance for the development of regenerative cellular therapies for better understanding of organ physiology and developmental biology. This study aims to maximise the clinically available data as well as patient benefit that can be generated from donated tissue. It also aims to reduce number of consent forms given to patients by consolidating and coordinating a number of related investigations.
The study aims are:
- To examine function and the immune response to stem cells and their differentiated progeny as well as development of immunomodulatory approaches to prevent their rejection.
- Generation of induced pluripotent stem cells (iPSCs) and their subsequent differentiation into functional cells as potential therapies.
- Generation of differentiated cells from native adult stem cells as cellular therapies.
- Investigation of organ physiology.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 92 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All deceased organ donors with informed consent from the donor family
排除标准
- •Donors aged <16
结局指标
主要结局
Number of donors from which induced Pluripotent Stem Cells were generated
时间窗: 5 years
次要结局
- Number of immunomodulatory therapies characterised(5 years)
- Number of stem cell lines for which the immune response was characterised(5 years)
- Levels of baseline and stimulated gut hormones detected(5 years)
研究者
Dr. Kourosh Saeb-Parsy
Mr Kourosh Saeb-Parsy
Cambridge University Hospitals NHS Foundation Trust