The Effect of Basis™ and High Intensity Interval Training (HIIT) on Muscle Metabolism and Exercise Performance in Healthy 18 - 35 Year Olds
试验速览
- 阶段
- 1 期
- 状态
- 撤回
- 发起方
- 试验地点
- 2
- 主要终点
- Mitochondrial function
研究概览
简要总结
This is a single-center, randomized, placebo-controlled pilot study to evaluate the effects of high intensity interval training (HIIT) and daily administration of BasisTM for 3 weeks, in 18-35 year old males.
The study will consist of a screening visit, baseline visit, followed by treatment and HIIT phase (3 weeks) and a post-supplementation, follow-up visit (this will occur 48 h (or more) after the final HIIT session). Following the screening phase, subjects who meet entry criteria will be randomly assigned to 1 of 2 treatment groups: recommended dose of BasisTM (250 mg Nicotinamide Riboside and 50 mg Pterostilbene) per day or matching-placebo in a 1:1 ratio.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •18 to 35 year old males
- •Body mass index between 18.5-30 kg.m-2
- •Ability to give informed consent
- •Recreationally active (defined in the present study as exercising once a week or more).
排除标准
- •Those regularly conducting HIIT or highly trained in endurance events (e.g. triathlete)
- •Currently taking supplements known to affect metabolism (e.g. ibuprofen, stimulants, vitamins, NR)
- •Taking prescribed medication
- •Consuming a vegan diet
- •Consuming a high fat, low carbohydrate diet
- •Habitual consumption of protein and/or dairy supplements (e.g. whey protein)
结局指标
主要结局
Mitochondrial function
时间窗: 3 weeks
Measured via high-resolution respirometry using the Oroboros Oxygraph
次要结局
- Physical activity levels using FitBit(3 weeks)
- Exercise Capacity(3 weeks)
- Mitochondrial proteins(3 weeks)
- Body Mass(3 weeks)
- Muscle strength(3 weeks)
- Muscle power(3 weeks)
- Percent Body Fat(3 weeks)
- Recovery via RESTQ(3 weeks)
- Blood pressure(3 weeks)
- Recovery via POMS(3 weeks)
- Height(3 weeks)