Distant Metastases and Long-Term Survival After Complete Resection of Neuroendocrine Tumors of the Appendix: An International Multicenter Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 278
- 试验地点
- 1
- 主要终点
- Clinically relevant relapse of aNET measuring 1 - 2 cm in a population based manner
研究概览
简要总结
The aim of the present project is to evaluate the frequency of distant metastases and clinically relevant relapse and mortality, respectively, of aNEN (Neuroendocrine Neoplasms of the Appendix) measuring 1 - 2 cm.
The investigators hypothesize that the mortality rate of aNET (Neuroendocrine Tumors of the Appendix) measuring 1 - 2cm is less than 1%. Furthermore, the investigators hypothesize that regional lymph node metastases of aNET measuring 1 - 2 cm are clinically not relevant and are not associated with reduced survival. The investigators therefore hypothesize that oncological right-sided hemicolectomy has no impact on long-term survival after complete resection of aNET measuring 1 - 2 cm and that the malignant potential quo ad vitam of these tumors is lower than the risk of oncological hemicolectomy.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The investigators will include all patients with aNET measuring 1 - 2 cm and complete resection between 01.01.2005 and 31.12.2010 of the primary tumor.
排除标准
- 未提供
结局指标
主要结局
Clinically relevant relapse of aNET measuring 1 - 2 cm in a population based manner
时间窗: 10 years
Clinically relevant mortality of aNET measuring 1 - 2 cm in a population based manner
时间窗: 10 years
Frequency of distant metastases in aNET measuring 1-2 cm
时间窗: 10 years
次要结局
- Association of histological risk factors in aNET measuring 1 - 2 cm and qualifying for oncological right-sided hemicolectomy according to ENETS guidelines with the occurrence of regional lymph node and distant metastases(10 years)
- Relationship between regional lymph node metastasis and survival in patients with aNET measuring 1 - 2 cm(10 years)
- Long-term survival after complete resection of aNET measuring 1 - 2 cm with or without oncological right-sided hemicolectomy(10 years)