NCT07242391招募中不适用
Menopausal Hormone Therapy And Neural Control Of Left Ventricular Function
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- Mayo Clinic
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Left ventricular stroke volume
研究概览
简要总结
The purpose of this study is to compare left ventricular stroke volume and heart rate responses to bursts of SNA between PMF using, and not using, MHT.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 45 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •>45-60< years of age
排除标准
- •Females between STRAW+10 stages -5 and 0
- •PMF in STRAW+10 stage +2
- •PMF using oral hormone therapy
- •Females who entered menopause due to a surgical procedure or in response to pharmacotherapy (e.g., gonadotrophin releasing hormone agonists or chemotherapy)
- •Heart disease such as hypertropic cardiomyopathy, congenital abnormalities, chronic heart failure, valve disease, and a history of myocardial infarction
- •Medications that impact the central nervous system including selective serotonin reuptake inhibitors, anxiolytics, sedatives, anticholinergic agents, dopamine, amphetamines, or wake-promoting agents (e.g., modafinil). Other medications will be evaluated on an individual basis by the PI.
- •Cardiovascular medications is also an exclusion criterion which includes those acting on the renin-angiotensin-aldosterone axis, adrenergic receptor antagonists, diuretics, nitrates, and calcium channel antagonists. Other medications will be evaluated on an individual basis by the PI.
- •Pregnancy
- •Raynaud's phenomenon
- •Sleep disorders
- •Shift workers
- •BMI ≥40.0kg/m2
- •Use of nicotine-containing products within the two years preceding study visits
- •Active cancer treatment
研究组 & 干预措施
Post-menopausal females using menopausal hormone therapy
Post menopausal females taking a clinically prescribed menopausal hormone therapy (i.e. pill, patch, etc.)
干预措施: Menopausal Hormone Therapy (Drug)
结局指标
主要结局
Left ventricular stroke volume
时间窗: Baseline
Left ventricular stroke volume is the amount of blood pumped from the left ventricle per heartbeat (mL)
次要结局
- Ventriculo-Arterial (VA) coupling(Baseline)
研究者
Joshua M. Bock
Principal Investigator
Mayo Clinic
研究点 (2)
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