Prevalence of Long-term Dental Effects of Chemotherapy in Childhood Cancer Survivors Diagnosed With Cancer Before the Age of 10
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 142
- 试验地点
- 2
- 主要终点
- Assessment of the caries experience by using the Decay Missing Filled Teeth score (DMFT)
研究概览
简要总结
To date, there are no methods for assessing the risk of oral developmental defects that could predict long-term adverse effects in childhood cancer survivors. Having such a method at our disposal would enable us to better assess the risk to develop those defects and will help us provide new prevention and treatment strategies to ensure a healthy oral development.
The aims of this study are :
- Assess the caries risk in childhood cancer survivors compared with a control group.
- Assess the dental development defects risk in childhood cancer survivors compared with a control group.
详细描述
This will be an international study comparing the Childhood Cancer Survivors (CCS) and a control group.
A questionnaire will be provided to the patients to gather information. A standard of care dental examination will then take place in a dental office in the Cliniques Universitaires Saint-Luc. We also collect medical data to complete the files.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 12 Years 至 36 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age below 10 at cancer diagnosis (for the CCS group).
- •Chemotherapy must have been used to treat the patient (For the CCS group).
- •The patient is 12 years old or older at the time of the follow-up appointment of the present study
排除标准
- •A patient who was diagnosed and treated after 10 years old.
- •Patient below 12 years old at time of study recruitment
- •Patients with syndrome or diseases that involve teeth impairment*
- •Pregnant patient
- •Refusal or inaptitude to undergo dental and radiographic examination
结局指标
主要结局
Assessment of the caries experience by using the Decay Missing Filled Teeth score (DMFT)
时间窗: Thoughout the entire study, approximately during 2 years
Assess the impact of the chemotherapy agents on the risk of ulterior caries development
次要结局
- Assessment of the prevalence of dental development defects (DDD)(Thoughout the entire study, approximately during 2 years)