Comparison of an Early Protocolized Rehabilitation (EPR) versus usual care in improving functional outcomes at 12 weeks in Pediatric Neurocritical Patients (PNP) of age 1-18 years: A Randomized Controlled Trial (EPR-PNP trial) - EPR-PNP

AIIMS Rishikesh0 个研究点目标入组 0 人开始时间: 待定最近更新: 2023年5月1日

试验速览

暂无简介。

•1. Children between ages 1 and 18 years
•2. Satisfying operational definition for neurocritical patient
•3. Premorbid Pediatric Cerebral Performance Category (PCPC) score of 1 or 2 within 2 weeks of onset of illness
•Pediatric Neurocritical Patients (PNP) for the purpose of the study will be defined as:
•I. Suffering from primary neurological illness with PCPC score of 3-5 at enrollment (or)
•II. Suffering from any other systemic illness on invasive or non-invasive mechanical ventilation with
•a. Evidence of metabolic, septic or hypertensive encephalopathy not completely reversible within 72 hours
•b. Coexisting predisposing factors towards hypoxic-ischemic encephalopathy (OI >15, OSI >7.5, requiring any CPR)

•1. Expected survival <24 hours (PSOFA score >20)
•2. Children with absence of brain stem reflexes (PCPC score of 6)
•3. Children requiring mechanical ventilation only during a perioperative period or for a period under the effect of sedatives/anesthetics for diagnostic procedures
•4. Catecholamine refractory shock for >48 hours during initial 72 hours of mechanical ventilation
•5. Major surgery involving vital internal organs performed or being planned within 24 hours
•6. Active bleeding severe enough to be life threatening or cause hemodynamic instability
•7. Uncontrolled raised intracranial pressure
•8. Uncontrolled status epilepticus
•9. Rapidly progressive neurodegenerative disease
•10. Already received mechanical ventilation for >72 hours

发起方