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临床试验/CTRI/2024/12/078068
CTRI/2024/12/078068尚未招募2 期

A Randomized comparative clinical study to evaluate efficacy of Simhasyadi kwath and kokilakshadi kwath in the management of Uttana Vatarakta(Gout)

DrSaloni Santosh Shah1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2024年12月20日最近更新:

试验速览

阶段
2 期
状态
尚未招募
发起方
入组人数
60
试验地点
1
主要终点
1)To study the efficacy of Simhasyadi Kwath and Kokilakshadi Kwath in reducing the Serum uric acid level & classical symptoms of Gout.

研究概览

简要总结

Illness has been human heritage from the beginning of his existence, and search for remedies to combat is perhaps equally old. Ample researches have been done till now on Vatarakta (Gout), still due to the adaptation of sedentary life style along with mental stress, consumption of non veg and highly rich protein diet, excessive alcohol intake are some of the precipitating factors which causes acute exacerbation of Vatarakta hence in present Era the condition is still on the high prevalence worldwide.

Currently in modern science non-steroidal anti-inflammatory drugs, Colchicine, Corticosteroids are being used to treat Gout. These medications may causes side effects such as Gastro Intestinal bleeding, Vomiting, Hepatotoxicity.

Therefore, it is necessary to find Proper Intervention which should be more effective and with fewer drawbacks. Ayurveda has advocated many formulations to manage Vatarakta condition which can be helpful in finding out better solution in the management of Gout also.

The drug Simhasyadi Kwath is selected for present clinical trial which consists of ingredients like Vasa, Laghupanchmool, Erandmool, Guduchi, Gokshur and praksheparth Erand tail, Saindhav, Hingu work together synergistically and are very beneficial in treating Shula, daha and Shotha yukt joints. The ingredients of this formulation possess the qualities like Vedanasthapan, Shothahar, Raktashodhana, Vatanulomana.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
None

入排标准

年龄范围
20.00 Year(s) 至 60.00 Year(s)(—)
性别
All

入选标准

  • Participants with classical sign & symptoms of Uttana Vatarakta i.e., Sandhi Shula, Sandhi Shoth, Sandhi daha, Sandhi sparsahatva, Sandhivaivarnya will be selected.
  • Participants with classical sign & symptoms of Vatarakta having raised serum Uric acid level.

排除标准

  • Participants who are suffering from any other known case of Immunosuppressed disease.
  • Pregnant and lactating women.
  • Participants taking uricosuric/xanthine oxidase inhibitor drugs and also immunosuppressive medications.
  • Participant diagnose with other than Gouty Arthritis such as Rheumatoid arthritis, Osteoarthritis, Systemic Lupus Erythematosus.
  • Complicated cases of Vatarakta by its upadravas like Mansakoth, Murchha, Moha, Visarpa, Pangulya etc.
  • Patient with uncontrolled comorbidities like Diabetes Mellitus, Hyper Tension.

结局指标

主要结局

1)To study the efficacy of Simhasyadi Kwath and Kokilakshadi Kwath in reducing the Serum uric acid level & classical symptoms of Gout.

时间窗: 21 Days with Follow-up on 7th, 14th and 22nd day.

次要结局

  • 1)To study the safety of Simhasyadi Kwath and Kokilakshadi Kwath in the cases of Gout.(2)To understand Samprapti of Uttana Vatarakta in detail.)

研究者

发起方
DrSaloni Santosh Shah
申办方类型
Other [self]
责任方
Principal Investigator
主要研究者

Dr.Saloni Santosh Shah.

Seth Govindaji Raoji Ayurved Mahavidyalaya,Solapur

研究点 (1)

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