Effects of Resveratrol Alone or in Combination With Piperine on Cerebral Blood Flow Parameters and Cognitive Performance in Humans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- Modulation of levels of total haemoglobin
研究概览
简要总结
Resveratrol is associated with a plethora of physiological effects in humans, including modulation of cerebral blood flow, despite apparently poor bioavailability. This study investigated whether the physiological effects of resveratrol could be affected when co-supplemented with piperine, an alkaloid which may be able to enhance the bioavailability of resveratrol.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Between the ages of 18-35 years old
- •Non-smoker
排除标准
- •Not proficient in English
- •Taking medication or herbal supplements
- •Pregnant or breast feeding
- •Heavy caffeine consumer
- •History of head trauma, migraines, learning difficulties, ADHD, gastrointestinal problems.
- •Food allergies of intolerances
研究组 & 干预措施
250mg trans- resveratrol
干预措施: Placebo (silica) (Other)
250mg trans-resveratrol with 20mg piperine
干预措施: Placebo (silica) (Other)
Placebo
干预措施: Placebo (silica) (Other)
250mg trans-resveratrol with 20mg piperine
干预措施: Trans- resveratrol (Dietary Supplement)
Placebo
干预措施: Trans- resveratrol (Dietary Supplement)
250mg trans- resveratrol
干预措施: Trans- resveratrol (Dietary Supplement)
结局指标
主要结局
Modulation of levels of total haemoglobin
时间窗: 80 minutes following treatment administration
Modulation of levels of deoxygenated haemoglobin
时间窗: 80 minutes following treatment administration
Modulation of levels of oxygenated haemoglobin
时间窗: 80 minutes following treatment administration
次要结局
- Number of participants displaying significant modulation of cognitive performance(40-80 minutes post dose)