Effect of Carotid Ultrasound-guided Fluid Management on Anesthetic-induced Hypotension in Elderly Patients Undergoing Gastrointestinal Surgery
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Occurrence of hypotension after anesthesia induction
研究概览
简要总结
The goal of this clinical trial is to learn about Whether carotid ultrasound guided fluid management can reduce the incidence of hypotension after general anesthesia induction in elderly patients undergoing gastrointestinal surgery.
The main question[s] it aims to answer are:
Whether fluid therapy reduces the incidence of general anaesthesia induced hypotension in elderly patients undergoing gastrointestinal surgery.
Whether carotid ultrasound can guide fluid management in elderly patients undergoing gastrointestinal surgery.
Participants will use carotid ultrasound to assess volume status. If volume is insufficient, fluid therapy will be selected until volume is sufficient, anesthesia will be then induced. If volume is sufficient, anesthesia will be directly induced. There is a comparison group: No carotid ultrasound will be used to assess the volume status of the patients, and anesthesia will be directly induced.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
盲法说明
In this study, researchers and subjects were not blind. Anesthesiologists and data collectors were blind. Researchers conducted carotid ultrasound guided fluid therapy for experimental groups according to the groups, anesthesiologists performed routine induction for patients in the two groups, data collectors collected data, and anesthesiologists and data collectors did not know the groups of subjects.
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 60-80 years old
- •gender unlimited
- •ASA: Grade I-Ⅲ
- •BMI:18-30kg/㎡
- •Patients undergoing elective gastrointestinal surgery under general anesthesia Informed consent
排除标准
- •Carotid artery stenosis ≥50%
- •Patients with heart valve disease
- •Patients with left ventricular ejection fraction < 50%
- •Patients with cardiac dysfunction (NYHA grade Ⅲ-Ⅳ and/or NTproBNP≥900pg/ml)
- •Patients Combined with renal insufficiency (creatinine ≥178μmol/L, and/or blood urea nitrogen > 9mmol/L)
- •Preoperative systolic blood pressure> 160mmHg or diastolic blood pressure > 100mmHg
- •Refuse to participate in the test
- •Patients participating in other clinical trials
结局指标
主要结局
Occurrence of hypotension after anesthesia induction
时间窗: General anesthesia induction from the beginning to 20 minutes after induction
Hypotension occurred from anesthesia induction to 20 minutes after induction in both groups.
次要结局
- postoperative delirium(Within 30 days after surgery)
- Postoperative acute kidney injury(Within 7 days after surgery)
- postoperative stroke(Within 30 days after surgery)
研究者
Min Su
Director,Principal Investigator, Clinical Professor
First Affiliated Hospital of Chongqing Medical University