NCT04715321Unknown不适用
Computed Tomography Perfusion Parameters Predict Vascular Pattern in Hepatocellular Carcinoma: A Prospective Study
Sun Yat-sen University1 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2013年2月15日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Predictive performance of CT perfusion
研究概览
简要总结
Distinct vascular patterns (ECTC or Non-ECTC) of tumors plays an important role in tumor migration, metastasis and drug resistant in hepatocellular carcinoma (HCC). However, there is no non-invasive method to predict vascular pattern in clinical. In the present study, we prospectively assess CT perfusion parameters for evaluation of the vascular pattern in HCC.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age over than 18 years old
- •tumor size of less than 5 cm
- •Child-Pugh A class liver function
- •an Eastern Cooperative Oncology Group performance status of 0
- •no previous treatment for HCC
- •pathological diagnosis of hepatocellular carcinoma
- •adequate organ function (white blood cell count ≥3.0 × 109/L, absolute neutrophil count ≥1.5 × 109/L, platelet count ≥75 × 109/L, aspartate transaminase and alanine transaminase≤5 × upper limit of the normal, creatinine clearance rate of ≤1.5 × upper limit of the normal, and left ventricular ejection ≥45%)
排除标准
- •Patients who received antitumor therapy before recurrence, including radiotherapy, transarterial chemoembolization, tyrosine kinase inhibitor, and immune checkpoint inhibitor
- •a known medical history of HIV infection
- •pregnancy or breastfeeding
- •portal vein tumor thrombosis or hepatic vein thrombosis detected by any routine imaging modality, including ultrasonography, dynamic contrast CT and MRI
- •any evidence of tumor metastasis or prior recurrence
- •hepatic decompensation
结局指标
主要结局
Predictive performance of CT perfusion
时间窗: 6 months
The primary outcome of our study is to evaluate the sensitivity and specifity of CT perfusion in predicting vascular pattern of HCC
次要结局
- Disease-free survival (DFS)(6 months)
- Overall survival (OS)(6 months)
研究者
Shi Ming
Professor
Sun Yat-sen University
研究点 (1)
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