Clinical and Genetic Markers of Bone Metabolism in Children Under One Year of Age in the Kazakh Population
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 245
- 试验地点
- 1
- 主要终点
- Optimization of the method for diagnosing bone metabolism disorders in children under one year old in the Kazakh population
研究概览
简要总结
The study of children under one year of age for molecular genetic testing-VDR (rs1544410, rs2228570), RANKL (rs9594738, rs9594759) with the study of the frequency distribution of alleles and genotypes by polymorphisms, analysis of the relationship of molecular genetic markers with indicators of bone metabolism.
详细描述
Children under the age of one year of Kazakh nationality born in Aktobe will be examined.
Each child included in the study will have an individual registration card, where information about the health status of the child and the health status of the mother during pregnancy will be filled in.
A biochemical analysis will be determined for the level of calcium, phosphorus, calcitonin, parathyroid hormone, osteocalcin, vitamin D in blood serum and deoxypyridinoline in urine.
Blood will be taken to determine the genetic polymorphism of VDR (rs1544410, rs2228570), RANKL (rs9594738, rs9594759).
The state of bone tissue remodeling (osteocalcin, vitamin D, Ca, P, calcitonin, deoxypyridinoline) will be revealed The frequencies of allelic variants of the VDR (rs1544410, rs2228570), RANKL (rs9594738, rs9594759) genes in children under the age of one year in the population of Kazakhstan were determined.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Day 至 1 Year（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children 0 -12 months old
排除标准
- •Musculoskeletal system diseases;
- •Severe chronic somatic diseases;
- •Supplementation of vitamin D in a therapeutic dose;
- •Lack of consent of the parents or legal representatives to participate in the study.
结局指标
主要结局
Optimization of the method for diagnosing bone metabolism disorders in children under one year old in the Kazakh population
时间窗: 2 years
The state of bone metabolism was assessed using the quantitative content of calcium, phosphorus, vitamin D, osteocalcin, and parathyroid hormone.
次要结局
未报告次要终点
研究者
Irina Kim
Principal investigator of Department of Children's diseases
West Kazakhstan Medical University