PreTerm RNA in Maternal Serum
试验速览
- 阶段
- 不适用
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Number of women with preterm labor that present a unique RNA cluster
研究概览
简要总结
Preterm birth is defined as a birth occurring before the completion of 37 weeks gestation. The incidence of preterm birth in Israel in the last years is around 7-8%.
Despite various diagnostic modalities as well as newly therapeutic approaches the incidence of preterm birth remains unchanged and is considered to be the leading cause of neonatal morbidity and mortality.
In the last decade, small RNAs have emerged as an important player in both physiological and pathophysiological responses. These single strands, non-coding regulatory RNA molecules are responsible for post transcriptional regulation of target genes. Hence, may provide a new opportunity for biomarkers discovery in the field of preterm birth.
The main objective of this study is to identify a distinctive expression profile of maternal circulating RNAs that will be used as biomarkers for preterm birth.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women with singleton pregnancy at 26-32 week of gestation with no clinical symptoms of preterm labor.
- •Women with singleton pregnancy 24-34 week of gestation who present to the labor suite with symptoms suspected for preterm labor.
- •Women with singleton pregnancy in term active labor (weeks 37-40).
排除标准
- •Exclusion criteria will include:
- •multiple gestation,
- •major fetal anomalies,
- •severe preeclampsia,
- •chronic steroid or immunosuppressive drug use,
- •active immunological illness,
- •and/or pregestational and gestational DM.
结局指标
主要结局
Number of women with preterm labor that present a unique RNA cluster
时间窗: 2 years
次要结局
未报告次要终点