NL-OMON47264已完成3 期
Duloxetine for chronic osteoarthritis pain; an important alternative? - DUO-trial
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 224
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •1) having hip or knee OA based on the clinical ACR criteria, and 2) having chronic pain (most days of the last three months) in hip or knee, and 3) either: (i) a contra-indication for NSAIDs; (ii) adverse reactions of NSAIDs; or (iii) insufficient benefit of NSAIDs.
排除标准
- •1) on waiting list for hip/knee replacement, and 2) use of antidepressants or neuropathic pain medication 3) contra-indication of duloxetine (use of Monoamine Oxidase Inhibitors, having uncontrolled narrow-angle glaucoma, in combination with (other) central nervous system acting drugs, in combination with thioridazine, hypersensitivity to duloxetine, disturbed liverfunction, renal insufficiency (creatinine clearance < 30ml/min), usage of strong CYP1A2-inhibitors and CYP2D6-inhibitors and substrates).
研究者
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