Disparities in Neurocognitive Impairment Among Hispanics/Latinos in the US With Parkinson's Disease: The Role of Cardiovascular Risk
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 4
- 主要终点
- Language (Letter Fluency)
研究概览
简要总结
This study will investigate disparities in neurocognitive impairment (NCI) among Hispanics/Latinos/as/x (henceforth Hispanics) living in the US-Mexico borderland of California or in North Carolina with Parkinson's Disease (PD) and determine mechanisms underlying these disparities. NCI is an important aspect of the clinical course of PD, particularly among Hispanics, who have increased prevalence of dementia. Among the many potential factors driving this disparity, the investigators chose to focus on a modifiable risk factor to which Hispanics are particularly vulnerable, and that has been linked to increased NCI, namely cardiovascular (CVD) risk (e.g., diabetes, hypertension, obesity).
详细描述
The proposed study will use a cross-sectional design to determine the presence of NCI in 120 persons with PD (age 40+), living in the US-Mexico borderland of California or in North Carolina, including 60 Hispanics and 60 non-Hispanic Whites. All participants will complete comprehensive neuromedical and neuropsychological evaluations, a blood draw and assessments of socio-cultural factors (e.g., health literacy, access to care, acculturation, bilingualism, discrimination, socioeconomic status). Using these data we will examine the extent to which CVD risk (e.g., diabetes, hypertension, obesity), PD severity and social determinants of health drive NCI among Hispanics with PD. The present proposal will capitalize on the infrastructure and expertise available at Duke University and will follow a community-based participatory research approach to complete the proposed study aims.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •40 years old and older
- •non-Hispanic Whites
- •Hispanics
- •All genders
- •Ability to provide consent
- •Diagnosed with Parkinson's Disease
排除标准
- •Other neurological illness/diagnosis
- •Injury that would affect cognition (i.e. stroke, closed head injury with loss of consciousness for longer than 30 minutes)
结局指标
主要结局
Language (Letter Fluency)
时间窗: Day 1 (day of enrollment)
Language (Animal Fluency)
时间窗: Day 1 (day of enrollment)
Language (Vegetable Fluency)
时间窗: Day 1 (day of enrollment)
Language (Multilingual Naming Test)
时间窗: Day 1 (day of enrollment)
Attention/Working Memory
时间窗: Day 1 (day of enrollment)
Number Span
Visual-Spatial skills
时间窗: Day 1 (day of enrollment)
Benson Figure Copy
Everyday Functioning
时间窗: Day 1 (day of enrollment)
Modified Lawton-Brody Instrumental Activities of Daily Living questionnaire
Executive Function
时间窗: Day 1 (day of enrollment)
WCST-64 (Wisconsin Card Sorting Test)
Verbal Learning and Memory
时间窗: Day 1 (day of enrollment)
Craft Story Learning \& Recall
Visual Learning and Memory
时间窗: Day 1 (day of enrollment)
Brief Visuospatial Memory Test - Revised, Benson Figure Delay
Diagnosis of MCI/dementia in PD
时间窗: Day 1 (day of enrollment)
Objective presence of MCI and dementia in PD will be determined via comprehensive diagnostic criteria
current cigarette smoking
时间窗: Day 1 (day of enrollment)
Self-report
diabetes mellitus
时间窗: Day 1 (day of enrollment)
fasting plasma glucose \>126 mg/dL, an HbA1c \>6.5%, or use of antihyperglycemic medications
hypercholesterolemia and dyslipidemia
时间窗: Day 1 (day of enrollment)
total cholesterol \>240 mg/dL, LDL cholesterol \>160 mg/dL, or HDL cholesterol \<40 mg/dL or on cholesterol-lowering medication
hypertension
时间窗: Day 1 (day of enrollment)
systolic blood pressure \>140 mm Hg, diastolic blood pressure \>90 mm Hg, or on antihypertensive medication
obesity
时间窗: Day 1 (day of enrollment)
BMI of \>30.0
Parkinson's disease severity
时间窗: Day 1 (day of enrollment)
Movement Disorders Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS)
Speed of Information Processing
时间窗: Day 1 (day of enrollment)
Trail Making Test A
次要结局
未报告次要终点