NCT01729702已完成不适用
Evaluation at Rest and Exercise of Clinical, Ultrasonic and Neurohormonal Parameters in Hypertrophic Cardiomyopathies
French Cardiology Society1 个研究点 分布在 1 个国家目标入组 131 人开始时间: 2009年4月1日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 131
- 试验地点
- 1
- 主要终点
- Plasmatic Neurohormonal measures: BNP - NT ProBNP - Troponine
研究概览
简要总结
The primary purpose of this study is to demonstrate that changes in plasma levels of circulating neurohormones (mainly BNP and NT-proBNP), measured at rest and post-exercise correlate with exercise functional limitation (assessed by exercise peak VO2) and exercise ultrasonic parameters (as left ventricular filling, obstruction, and mitral regurgitation)
详细描述
The secondary purposes are to study the kinetics of secretions of natriuretic peptides, and their relationships with extent of MRI myocardial fibrosis with the degree of exercise functional limitation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •- Age 18 to 75 years
- •Primary (sarcomeric) hypertrophic cardiomyopathy, obstructive or non obstructive, with studies of exercise peak oxygen consumption and cardiac MRI with gadolinium late-enhancement
- •Informed consent
- •Patient with a social insurance Patient at rest
- •- Age 18 to 75 years
- •Primary (sarcomeric) hypertrophic cardiomyopathy, obstructive or non obstructive
- •Informed consent
- •Patient with a social insurance
排除标准
- •- Insufficient echogenicity
- •Permanent atrial fibrillation
- •Complete BBB on the ECG
- •LVEF < 35 %
- •Previous septal ablation (surgical or percutaneous)
- •Simultaneous participation to another biomedical research
- •If exercise needed:
- •contraindication to exercise : hemodynamic instability, uncontrolled high blood pressure (>220/120 mmHg), severe aortic stenosis
- •Inability to exercise (muscular, pulmonary, elderly patient)
研究组 & 干预措施
single group - consecutive patients
Other
干预措施: blood sample collection (Other)
结局指标
主要结局
Plasmatic Neurohormonal measures: BNP - NT ProBNP - Troponine
时间窗: Day 1 at rest and during exercise
次要结局
未报告次要终点
研究者
研究点 (1)
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