REmission MEchanisms in Depression
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 72
研究概览
简要总结
Published conference abstracts: 2009 results in: https://doi.org/10.1016/S0924-977X(09)70565-6 (added 26/11/2019) 2009 results in: https://doi.org/10.1016/S0924-977X(09)70594-2 (added 26/11/2019) 2009 results in: Arnone D, Pegg EJ, McKie S, Downey D, Elliott R, Williams SR, Deakin JFW, Anderson IM (2009) Current major depression but not remitted major depression shows increased neural responses to sad facial expressions. Journal of Psychopharmacology Suppl to Vol 23(6), A26 (added 26/11/2019) 2009 results in: Pegg EJ, Arnone D, McKie S, Elliott R, Deakin JFW, Anderson IM (2009) Citalopram treatment increases neural responses to positive words and decreases responses to negative words in depression. Journal of Psychopharmacology Suppl to Vol 23(6), A25 (added 26/11/2019) Refereed papers: 2012 results in: https://www.ncbi.nlm.nih.gov/pubmed/22854930 (added 26/11/2019) 2013 results in: https://www.ncbi.nlm.nih.gov/pubmed/23128153 (added 26/11/2019) 2019 results in: https://www.ncbi.nlm.nih.gov/pubmed/30877271 (added 26/11/2019)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Depressed subjects:
- •1. DSM-IV major depressive episode with a Montgomery Asberg Depression Rating Scale (MADRS) score greater than 20
- •2. Psychotropic drug-free for greater than 2 weeks (2 months for fluoxetine)
- •3. Psychiatrically well
- •4. Good physical health
- •5. Aged 18 - 55 years, either sex
排除标准
- •Depressed subjects:
- •1. Duration of depressive episode greater than 1 year or depression superimposed on dysthymia
- •2. Failure to respond to 2 antidepressants given for 6 weeks at an adequate dose in current episode
- •3. Failure to respond to citalopram or escitalopram in current episode
- •4. Allergy or intolerance to citalopram or escitalopram
- •5. Contraindications to selective serotonin reuptake inhibitor (SSRI) treatment (e.g., history of peptic ulcer/gasterointestinal [GI] bleeding or taking non-steroidal anti-inflammatory drugs [NSAIDs], in the absence of concurrent ulcer-protective treatment)
- •6. Other concurrent psychotropic medication except for small stable doses of short acting hypnotics
- •7. Electroconvulsive therapy (ECT) or lithium in current episode
- •8. Significant suicidal risk or likely need for other psychiatric intervention during the study period
- •9. Other current co-morbid Axis I psychiatric disorders except anxiety disorders (excluding OCD) secondary to depression
- •10. Primary cluster A or B Axis II (personality) disorder
- •11. History of psychotic, bipolar or organic psychiatric disorder
- •12. Personal psychiatric history including Axis II (personality) disorder
- •13. Significant family psychiatric history (eg psychosis, recurrent affective disorder)
- •14. Psychotropic medication
- •15. Medical condition that might compromise subject safety or interfere with interpretation of results
- •16. History of significant head trauma (loss of consciousness greater than 5 minutes)
- •17. Current medication for a medical condition that would compromise subject safety or interfere with interpretation of results in the judgement of the investigator (e.g., possible exceptions intermittent analgesics, contraceptive pill, occasional inhaler for mild asthma)
- •18. Subjects whose English is insufficiently good to enable them to validly complete the questionnaires or perform simple computer-based tasks
- •19. Pregnancy or no effective contraception in women of childbearing age
- •20. Any illicit drug use in the last 2 months and a lifetime history of a DSM-IV substance or alcohol misuse disorder
- •21. Current Alcohol use above 14 units/week for women and 21 units/week for men
- •22. Excessive caffeine use (greater than 6 cups of coffee/day)
- •23. Smoking greater than 10 cigarettes/day
- •24. Contraindications to scanning (determined by standard screening instrument)
- •25. Likely not to be able to complete the full study for any reason