Effects of ischemia and tissue hypoxia in the pathogenesis of ulcerative colitis: a case control study

Faculty of Medicine, Tehran University of Medical science, Tehran, Iran0 个研究点目标入组 60 人开始时间: 待定最近更新: 2018年2月22日

适应症

试验速览

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•We conducted a randomised clinical trial study to assess the role of ischemia in UC. 20 patients with UC, 20 people without any history of bowel disease and ten paraffin wax embedded tissue species from mesenteric ischemia and ten paraffin wax embedded tissue species include infectious colitis entered the study. UC is diagnosed by clinical symptoms, sigmoidoscopy or colonoscopy findings and pathological species on biopsy.1Patients who took NSAIDs, vasodilators, corticosteroids (some studies showed they might affect tissue oxygenation) and patients with past medical history of ischemic heart disease, pulmonary disorders (COPD, asthma), severe anemia and vascular disease ( vasculitis) and Diabetes which can cause tissue hypoxia were excluded. Control group included 10 people who were referred for screening with all the features mentioned above except history of clinical or colonoscopic bowel disease. Both group had the same age, sex and lived in the same height above the sea level.

发起方

Faculty of Medicine, Tehran University of Medical science, Tehran, Iran