Otoacoustics Emissions Contralateral Supression Test
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 49
- 试验地点
- 2
- 主要终点
- Contralateral supression
研究概览
简要总结
This study investigates how obesity may affect the auditory system in individuals with Multiple Sclerosis (MS). Specifically, it examines the brain's ability to process and suppress sounds (contralateral suppression).
The test is painless and brief. It provides information about the condition of the auditory nerve pathways. The goal is to better understand how obesity may influence this system and to improve follow-up and support for individuals with MS.
详细描述
This study investigates the potential impact of obesity on auditory efferent system function in individuals diagnosed with Multiple Sclerosis (MS). Specifically, it focuses on assessing contralateral suppression of Distortion Product Otoacoustic Emissions (DPOAEs), a non-invasive, objective method for evaluating the integrity of the cochlear outer hair cells and the medial olivocochlear (MOC) efferent system.
Participants will undergo a brief and painless auditory test, during which DPOAEs are recorded both in quiet and with contralateral acoustic stimulation. This approach allows for the assessment of the brainstem's ability to suppress cochlear responses, which reflects central auditory processing capabilities.
By comparing suppression patterns across participants with different body mass index (BMI) classifications, the study aims to identify whether obesity contributes to functional changes in the auditory efferent system among MS patients.
The outcomes of this research may enhance the understanding of how metabolic factors such as obesity interact with neurological conditions like MS, potentially guiding more personalized clinical monitoring and interventions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
盲法说明
This is an observational study with no intervention; therefore, no masking was applied. All participants and investigators were aware of the group assignments (obese vs. non-obese), and no parties beyond those listed were masked.
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Eligibility Criteria Minimum Age: 18 Years Maximum Age: 50 Years Sex: All Gender Based: No Accepts Healthy Volunteers: No
- •Inclusion Criteria:
- •Ability to cooperate with the applied scales and auditory tests
- •Normal findings in otoscopic examination (ear, nose, and throat evaluation)
- •Absence of any neurological, psychiatric, or metabolic disease other than Multiple Sclerosis (MS)
- •No history of significant noise exposure
- •For female participants: not pregnant and not in the menstrual period
排除标准
- •Presence of active middle ear pathology (e.g., otitis media, tympanic membrane perforation)
- •Abnormal tympanometric findings
- •Hearing loss exceeding 20 dB HL at any frequency between 500-4000 Hz
- •Neurological or psychiatric disorders other than MS
- •History of ear surgery or otologic trauma
- •Use of medications known to affect auditory function (e.g., ototoxic drugs)
- •Inability to cooperate with audiological testing
- •Diagnosis of metabolic or endocrine disorders (e.g., uncontrolled diabetes, thyroid dysfunction)
- •Body Mass Index (BMI) below 18.5 (underweight) or above 40 (morbid obesity)
结局指标
主要结局
Contralateral supression
时间窗: Within 12 months of MS diagnosis
Comparison of contralateral suppression values of distortion product otoacoustic emissions (DPOAEs) between obese and non-obese patients with Multiple Sclerosis (MS) at multiple frequencies (1 kHz, 1.4 kHz, 2 kHz, 2.8 kHz, 4 kHz, 5.6 kHz, and 8 kHz).
次要结局
- DPOAE Amplitude Levels(Within 12 months of MS diagnosis)
研究者
Asuman Kucukoner
Principal Investigator
Ondokuz Mayıs University