NCT01150734已完成不适用
Transcranial Direct Current Stimulation (tDCS)-Boosted Changes in Muscle Evoked Potentials (MEP) in Depressed and Schizophrenic Patients Reveal Deficits in Neuromodulation
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Decreased MEP amplitudes in depressed patients
研究概览
简要总结
Muscle evoked potentials (MEP) are supposed to different in schizophrenic and depressed patients, compared to a sample of healthy volunteers. Transcranial Magnetic Stimulation (TMS)-evoked MEP are measured in all three groups at baseline and after tDCS (2 mA, 20 minutes). MEP amplitudes are supposed to normalize quickly in healthy volunteers, to stay diminished in depressed patients and to stay elevated in schizophrenic patients. These differences should disappear after regular pharmacological treatment. Outcome measures will be done in week 2 and week 4.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •The patient must be in the condition to understand the patient-information, as well as the necessary examinations.
- •He/she must be able to give a written consent.
- •No medication at least three weeks before enrollment.
排除标准
- •Existence of a care/legal incapacity
- •Existing pregnancy
- •Severe psychiatric illness (with exception of affective disorder)
- •Acute suicidality
- •Drug-, medication- or alcohol dependence
- •Dementia according to DSM IV / ICD 10-criterions
- •Severe brain infarctus in the anamnesis
- •Indications of structural damage of the basal ganglia or the brain stem
- •Severe neurological disorders (e.g. M. Parkinson, epilepsy, discus-prolapse, dementia, systemic neurological illnesses, normal pressure hydrocephalus, cerebrovascular diseases, elevated intracranial pressure, in the last 6 months, polyneuropathies).
- •Severe other medical conditions, like manifest arterial hypertonia, severe heart disease, pacemakers, respiratory failure, malignant illnesses all type, also in the history, active infectious diseases, skeletal disorders (like M. Paget, osteoporosis with spontaneous fractures, fresh fractures) Other circumstances, that speaks against a participation of the patient pinion of Medical Doctor at this study.
结局指标
主要结局
Decreased MEP amplitudes in depressed patients
时间窗: at baseline
MEP amplitudes are supposed to be lower than in healthy controls or schizophrenic patients
次要结局
- Elevated MEP amplitudes in schizophrenic patients(at baseline)
- Normalization of MEP amplitudes after drug treatment(4 weeks after baseline)
研究者
研究点 (1)
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