Effect Of Non-Surgical Periodontal Treatment On Endogenous Anti-Inflammatory Lipid Mediators In Patients With Chronic Periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Lipoxin A4 levels
研究概览
简要总结
The aim of this study was to evaluate the levels of lipoxin A4 (LXA4), prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) in gingival crevicular fluid (GCF) and saliva in individuals with periodontal healthy and chronic periodontitis. In addition, the investigators evaluated the levels of these mediators after non-surgical periodontal treatment in patients with chronic periodontitis. A total of 20 subjects, 10 patients with chronic periodontitis (CP) and 10 periodontally healthy individuals were included in the study. Clinical parameters including plaque index (PI), gingival index (GI), probing depth (PD) and clinical attachment levels (CAL) were recorded. GCF and saliva samples were obtained at the beginning of the study from all individuals. GCF and saliva samples were re-collected from patients with CP at 1 month after non surgical periodontal therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Have at least 20 natural teeth, excluding third molars.
- •Chronic periodontitis patients had at least two non-adjacent sites per quadrant with probing depth (PD) ≥ 5 mm and clinical attachment level (CAL) ≥ 5 mm with gingival inflammation, and alveolar bone loss affecting >30% of the teeth, as detected on clinical and radiographical examinations.
- •Periodontally healthy control group had no sign of gingival inflammation, no PD > 3mm and no evidence of attachment or bone loss.
排除标准
- •History of systemic disease.
- •Regular use of any drugs which can effect the immune system or inflammatory response in the 6 months preceding the start of the study.
- •Periodontal treatment during last 6 months that could affect periodontal status.
- •History of radiotherapy or chemotherapy.
- •Ongoing orthodontic treatment.
- •Aggressive periodontitis.
- •Current pregnancy, lactation or menopause.
研究组 & 干预措施
Control
Periodontally healthy group
Chronic Periodontitis
Patients with chronic periodontitis
干预措施: Non-surgical periodontal treatment (Procedure)
结局指标
主要结局
Lipoxin A4 levels
时间窗: 1st month
change of gingival crevicular fluid and salivary Lipoxin A4 levels from baseline at 1st month
次要结局
- Leukotriene B4(1st month)
- Prostaglandin E2 levels(1st month)
研究者
Ceren Gökmenoğlu
Principal invesitgator
T.C. ORDU ÜNİVERSİTESİ