The Acute Effect of Functional Crackers, Enriched With Grape Seed Flour or With Barley Flour and β-glucans, on Postprandial Glycemic, Lipemic and Antioxidant Metabolism
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- Total Antioxidant Capacity
研究概览
简要总结
The aim of this interventional study was to investigate the postprandial effect of two types of functional crackers, with 10% grape seed flour or 40% barley flour, enriched with β-glucan, in metabolic biomarkers of healthy participants.
详细描述
A pilot cross-over, controlled, randomized and single-blinded, intervention-clinical trial was carried out, in twelve healthy men and women, aged nineteen to sixty-five years, after random allocation into the control, the grape and the barley interventional groups, received a high-fat and high-carbohydrate meal, containing wheat flour or wheat and 10% grape seed flour or wheat and 40% barley flour, enriched with β-glucan, crackers. Participants consumed the same meals, allocating in cross-over order, with 1 washout week after each trial period. Differences on the metabolism of postprandial serum total, High Density Lipoprotein (HDL-), Low Density Lipoprotein (LDL-) cholesterol, glucose, triglycerides and uric acid levels, as well as of plasma total antioxidant capacity according to Ferric Reducing Antioxidant Power method, were determined between groups in fasting, thirty minutes, one and a half hour, and three hours after meal intake.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Single (Participant)
盲法说明
Only investigators knew the group in which each participant were enrolled.
入排标准
- 年龄范围
- 19 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 19-65 years
排除标准
- •Age over 65 years old
- •History of chronic illness including type I and II diabetes (hemoglobin A1c-HbA1c > 5%)
- •Abnormal Body Mass Index (BMI) (>25 kg/m2)
- •Alcohol overconsumption (>40 g alcohol/day)
- •Abnormal hematological and biochemical profiles (cholesterol > 6.8 mM, triglycerides > 2.8 mM, glucose > 6.11 mM)
研究组 & 干预措施
Control wheat crackers
Volunteers consumed 80g of white bread, 30g of full fat butter and 55g of wheat flour crackers.
Grape seed flour crackers
Volunteers consumed 80g of white bread, 30g of full fat butter and 55g of wheat flour crackers, enriched with 10% grape seed flour crackers.
干预措施: Functional crackers enriched with grape seed flour (Other)
Barley flour and β-glucan crackers
Volunteers consumed 80g of white bread, 30g of full fat butter and 55g of 60% wheat flour and 40% barley flour crackers, enriched with β-glucan
干预措施: Functional crackers with 40% barley flour and enriched with β-glucans (Other)
结局指标
主要结局
Total Antioxidant Capacity
时间窗: 3 hours
Total Antioxidant Capacity concentration changes from baseline at 3 hours
Glucose
时间窗: 3 hours
Glucose concentration changes from baseline at 3hours
次要结局
- High Density Lipoprotein cholesterol(3 hours)
- Low Density Lipoprotein cholesterol(3 hours)
- Total cholesterol(3 hours)
- Triglycerides(3 hours)
- Uric Acid(3 hours)