Pulse EnRiched Food and Exercise Clinical Trials (PERFECT Project): Part 1 - Acute Effects of Pulse Ingredients in Snack Products on Appetite, Blood Glucose, and Food Intake in Adults - Study 1
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Manitoba
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Food Intake
Study Overview
Brief Summary
The objectives are to test the acute effects of different extruded pulse snacks on: 1) post-prandial blood glucose, insulin and appetite for two hours, and 2) food intake two hours following consumption of pulse products.
The investigators hypothesize that snack products containing pulse ingredients will lead to lower blood glucose, insulin, appetite and food intake responses compared to non-pulse snack products.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Prevention
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Normoglycemic (<5.6 mmol/L) and normotensive (systolic blood pressure <140 mm Hg and diastolic blood pressure below < 90 mm Hg)
- •BMI of 18.5-29.9 kg/m2
Exclusion Criteria
- •Restrained eaters
- •Regularly skip breakfast
- •Those on medications that may influence study outcomes or have experienced any gastrointestinal related health conditions/surgeries over the past year
- •Competitive sports or athletic training at a high intensity
- •Those unable to walk for an hour continuously
Arms & Interventions
Extruded snack with pinto bean flour
60% corn flour and 40% pinto bean flour
Intervention: Pinto bean flour (Other)
Extruded snack control
100% corn flour
Intervention: Control (Other)
Extruded snack with small particle size pea flour
60% corn flour and 40% small particle size pea flour
Intervention: Small particle size pea flour (Other)
Extruded snack with large particle size pea flour
60% corn flour and 40% large particle size pea flour
Intervention: Large particle size pea flour (Other)
Extruded snack with lentil flour
60% corn flour and 40% lentil flour
Intervention: Lentil flour (Other)
Extruded snack navy bean flour
60% corn flour and 40% navy bean flour
Intervention: Navy bean flour (Other)
Outcomes
Primary Outcomes
Food Intake
Time Frame: at 120 min
Ad-libitum meal
Subjective Appetite
Time Frame: 0-200 min
Measured by VAS questionnaire at 12 time points used to calculate area under curve (AUC) (Composite measure)
Plasma Glucose and Insulin Concentrations
Time Frame: 0 - 200 min
Measured in blood using intravenous catheter at 12 time points and used to calculate area under curve (AUC). Glucose will be determined by automated methods using Abbot Spectrum CCX Analyzer, and Insulin will be measured by commercially available RIA kits (Composite measure)
Secondary Outcomes
- Physical Comfort(0-200 min)
- Palatability of meal(at 140 minutes)
- Palatability of treatments(at 5 minutes)
- Energy and Fatigue(0-200 min)