NCT02694367已完成不适用
MAP Kinase Signaling Pathways Through ERK and p-ERK Protein in Human Placenta of Women With Recurrent Miscarriage
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 39
- 试验地点
- 1
- 主要终点
- The levels of ERK and AKT in placenta
研究概览
简要总结
The present study is based on hypotheses that some as yet unknown genetic factors may result in recurrent miscarriage (RM). Consequently, the main aim of this study was to gain new information about the underlying genetic causes of RM in the Egyptian population and to investigate the expression of ERK and p-ERK protein in human placenta and their corresponding tissue, to assess the significance of MAPK signal pathway in progression of recurrent miscarriage and PI3K-Akt Pathway.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Gestational age less than 12 weeks.
- •no uterine abnormalities (examined by ultrasonography or hysterosonogram)
- •previous history of RM, defined as two or more consecutive miscarriages
排除标准
- •Gestational age 12 weeks or more.
- •Endocrine etiology like (thyroid dysfunction, and uncontrolled diabetes mellitus).
- •Antiphospholipid syndrome, inherited thrombophilias, alloimmune causes.
- •Uterine anatomic anomalies
结局指标
主要结局
The levels of ERK and AKT in placenta
时间窗: 48 hours
次要结局
未报告次要终点
研究者
研究点 (1)
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