Effects of Dietary Protein on Undesirable Postprandial Events in Overweight Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Endothelial dysfunction
研究概览
简要总结
Dietary protein differing by their amino acid composition could modulate undesirable metabolic and functional responses to a meal rich in saturated fat and sugars. This study aims at examining the specific effects of dairy protein with different cysteine contents on the postprandial undesirables effects elicited by the ingestion of a high fat meal in overweight subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •BMI between 25 and 30
- •Waist circumference > 94 cm
排除标准
- •Allergy to milk protein
- •Abusive drug consumption
- •Hypertension, diabetes
- •High level of physical activity
研究组 & 干预措施
Milk soluble protein
Protein source in the high fat meal are milk soluble protein
干预措施: Postprandial metabolic and functional measures (Dietary Supplement)
Alpha lactalbumin
Protein source in the high fat meal is alpha-lactalbumin
干预措施: Postprandial metabolic and functional measures (Dietary Supplement)
Casein
Protein source in the high fat meal is casein
干预措施: Postprandial metabolic and functional measures (Dietary Supplement)
结局指标
主要结局
Endothelial dysfunction
时间窗: 0-2-4-6 hours (after meal ingestion)
次要结局
- Postprandial inflammation(0-0.5-1-1.5-2-3-4-6 hours (after meal ingestion))
研究者
Robert Benamouzig
Professor
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement