Pharmacokinetics and Posology of Vancomycin in Adults Receiving ECMO
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- pharmacokinetic parameters
研究概览
简要总结
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Vancomycin is a drug that requires precise dosing and close monitoring to avoid drug toxicity.
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There is limited data on the change of vancomycin pharmacokinetics in patients who need extracorporeal membrane oxygenation (ECMO).
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This control trial is to understand:
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whether the pharmacokinetics of vancomycin is influenced by the use ECMO
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design the most appropriate dose of vancomycin in adult patients using ECMO.
详细描述
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Vancomycin is a drug that requires precise dosing and close monitoring to avoid drug toxicity.
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Oftentimes it is used in intensive care units (ICU) for patients who need a life-saving machine for heart and lung failure called extracorporeal membrane oxygenation (ECMO).
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There is limited data on the change of vancomycin pharmacokinetics in these patients.
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This is a control trial using ICU patients who need vancomycin but not ECMO as a control to understand:
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whether the pharmacokinetics of vancomycin is influenced by the use ECMO
-
design the most appropriate dose of vancomycin in adult patients using ECMO.
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After the 4th dose of vancomycin, blood was drawn at appropriate time spots (1 mL each) to determine the time concentration curve and to calculate the pharmacokinetic parameters for 2 groups of patients to determine if there is any difference.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •receiving ECMO for study group
- •without ECMO for control group (sex, age, creatinine clearance match with study group)
排除标准
- •severe burn (>30-40% BSA)
- •receiving continuous renal replacement therapy or hemodialysis concurrently
结局指标
主要结局
pharmacokinetic parameters
次要结局
未报告次要终点