Influence of External Dead Space on Volumetric Capnography Derived Parameters in Mechanically Ventilated COVID-19 Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- change in carbon dioxide elimination (VCO2) i.e. ml CO2 eliminated/minute
研究概览
简要总结
The objective is to investigate the efficacy of volumetric capnography to detect changes in dead space, CO2 elimination and shape factor parameters before and after disconnection of external dead space in ventilated COVID-19 patients.
详细描述
Covid-19 patients under mechanical ventilation are currently managed with a lung protective strategy derived from ARDSnet recommendations. In order to minimize the risk of spread of coronavirus, filters and associated respiratory tubing are incorporated to the breathing circuit, thus increasing apparatus dead space with subsequent increase in dead space ventilation. Considering the already often compromised ability for these patients to adequately clear carbon dioxide (VCO2), adding an external dead space can potentially have a substantial impact on CO2 homeostasis. The study will use volumetric capnography (Vcap) to investigate the influence of external dead space on VCO2 and calculated alveolar dead space.
Objective: 1) To investigate the efficacy of Vcap to detect changes in dead space, VCO2 and shape factor parameters before and after disconnection of external dead space.
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To register the external dead space impact on arterial carbon dioxide tension (PaCO2).
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To calculate the alveolar dead space based on Vcap data and arterial blood gas analysis results.
Design and setting: Prospective observational study in an intensive care center for Covid-19 patients in a university hospital.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Covid-19 positive patients of all age groups under mechanical ventilation
排除标准
- •Exclusion criteria is ongoing ECMO treatment
研究组 & 干预措施
dead space removal
external dead space will be removed and Vcap parameters (VCO2, PaCO2 and alveolar dead space) recorded before and after.
干预措施: Removal of dead space filter (Other)
结局指标
主要结局
change in carbon dioxide elimination (VCO2) i.e. ml CO2 eliminated/minute
时间窗: 60 minutes
VCO2 is expected to increase after removal of the external dead space
次要结局
- Changes in alveolar dead space (a Vcap derived parameter)(60 minutes)
- Changes in arterial carbon dioxide tension (PaCO2).(60 minutes)
研究者
Jacob Karlsson
MD PhD
Karolinska Institutet