ACTRN12612000270819已完成4 期
Efficacy of very infrequent zoledronic acid on vertebral fractures and bone mineral density in early postmenopausal women
Dr Mark Bolland0 个研究点目标入组 1,054 人开始时间: 2012年3月6日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 1,054
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Prevention
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 50 Years 至 60 Years（—）
- 性别
- Female
入选标准
- •Postmenopausal women aged 50-60 years.
- •Bone mineral density T score at the lumbar spine, femoral neck or total hip < 0
排除标准
- •Bone mineral density T score <-2.5 at the total hip, femoral neck or lumbar spine.
- •Renal impairment (estimated glomerular filtration rate > 45 ml/min).
- •Untreated hypothyroidism or hyperthyroidism.
- •Chronic liver disease.
- •Concurrent major systemic illness, including malignancy.
- •Active major gastrointestinal disease.
- •Metabolic bone diseases.
- •Previous fragility fracture of the hip or spine.
- •Current or past use of bisphosphonate therapy within 12 months, or past zoledronic acid use.
- •Use of oral glucocorticoid drugs equivalent to an average dose of at least prednisone 2.5mg/day during the preceding 6 months.
- •Use of hormone replacement therapy within 12 months
研究者
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