The Effect of Erigeron Injection on Acute Cerebral Infarction Serum VEGF, MMP-9 and EPC Levels
试验速览
- 阶段
- 4 期
- 入组人数
- 60
- 主要终点
- the serum level of VEGF,MMP-9 and EPC
研究概览
简要总结
To study the effects of Erigeron Injection on human serum VEGF, MMP-9 and EPC levels after acute cerebral infarction,test is made by random double-blind controlled.patients with acute cerebral infarction were divided randomly into erigeron injection+aspirin group,aspirin group,and health people. The main indexes are the serum level of VEGF, MMP-9 and EPC.The review is made by the reference to NIHSS and so on. So, Erigeron Injection have the function of promoting angiogenesis in multiple targets through this test.
详细描述
OBJECTIVE
To study the effects of Erigeron Injection on human serum VEGF, MMP-9 and EPC levels after acute cerebral infarction.
METHOD:
40 patients with acute cerebral infarction(in accordance with the inclusion criteria) were divided randomly into erigeron injection+aspirin group,aspirin group,and 20 health people. Erigeron injection+aspirin group and aspirin group drew peripheral blood on the prior treatment,the posttreatment 1th, 3th and 7th day,and tested the level of VEGF, MMP-9 and EPC.Tested the health people one time.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients aged no younger than 18yrs
- •attack within 72 hours
- •NIHSS score in the 2-25 points
- •Ischemic Stroke occurred for the first time, or with a history of stroke disease but without sequelae
- •Signed the informed consents
排除标准
- •patients aged younger than 18yrs
- •Patients with tumor, coronary heart disease, valvular heart disease, psoriasis, rheumatism, hematologic diseases, infertility, varieties of acute inflammation
- •Patients with severe cognitive impairment
- •Refused to cooperate or been unable to cooperation for neurological disorders
- •Cerebral hemorrhage or hemorrhagic cerebral infarction
- •Unstable vital signs dued to massive cerebral infarction
- •Patients with serious heart, liver and renal insufficiency
研究组 & 干预措施
Erigeron Injection
Erigeron Injection, 30ml,qd,i.v., for 7 days
干预措施: Erigeron Injection (Drug)
placebo
normal saline, 500ml,i.v.,qd, for 7 days
干预措施: placebo (Drug)
结局指标
主要结局
the serum level of VEGF,MMP-9 and EPC
时间窗: 0-7days
次要结局
- National Institute of Health of stroke scale(0-7days)