NCT02584946已完成不适用
Effect of Avenanthramides Supplement on Exercise-induced Physiological and Psychological Changes
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 主要终点
- Mean and SD of plasma concentrations of Creatine Kinase
研究概览
简要总结
The aim of the proposed study is to examine whether long-term dietary supplementation (8 weeks) of an oat flour cookie rich in avenanthramides (AVA) could enhance blood antioxidant capacity and reduce blood inflammatory markers after a downhill running (DR) protocol among human subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male and female non-obese subjects (18kg/M2<BMI<28kg/M2) (age 20-45 years) will be recruited from the Twin Cities community. All participants will sign informed consent approved by UMN-IRB and are willing to avoid oat consumption and rigorous physical activity the day prior to and through test and to consume a low-polyphenol diet for 1 week prior to the study. The foods rich in polyphenols include all berries, apples, pears, citrus fruits, fruit juices, onions, chocolate, wine, coffee, tea, beans, nuts, soy products and most spices
排除标准
- •Presence of GI conditions that interfere with absorption;
- •Clinically significant endocrine, cardiovascular, pulmonary, renal, hepatic, pancreatic, biliary or neurologic disorders;
- •Major trauma or surgery within 3 months of visit;
- •Cancer in the prior 2 years;
- •Allergic to oat products;
- •Women who are pregnant or lactating;
- •Drinking alcohol >5 drinks/week;
- •Using nutraceuticals;
- •Blood pressure medication;
- •NSAID (>800 mg ibuprofen/week)
- •Vitamin supplementation
- •Anticoagulants or hypoglycemic drugs
- •Oat products consumption and rigorous physical activity the day before the test and consumption of a high-polyphenol diet in week prior to the test.
- •Moderate-intensity cardiorespiratory exercise training for ≥30 min•d-1 on ≥5 d•wk-1 for a total of ≥150 min•wk-1, vigorous-intensity cardiorespiratory exercise training for ≥20 min•d-1 on ≥3 d•wk-1 (≥75 min•wk-1), or a combination of moderate- and vigorous-intensity exercise to achieve a total energy expenditure of ≥500-1000 MET•min•wk-1
结局指标
主要结局
Mean and SD of plasma concentrations of Creatine Kinase
时间窗: 0-72 hours
次要结局
- Mean and SD of plasma concentrations of TNF-α(0-72 hours)
- Mean and SD of plasma concentrations of IL-6(0-72 hours)
- Mean and SD of plasma concentrations of ICAM-1, VCAM-1, NF-κB (P65), NRB, NF-κB binding to DNA, 4-Hydroxynenenol, F2-isoprostane(0-72 hours)
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