Prevalence of and Prognostic Impact of Bronchiectasis in COPD Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Prevalence of Bronchiectasis in COPD
研究概览
简要总结
The identification of bronchiectasis in COPD has been defined as a different clinical COPD phenotype with greater symptomatic severity, more frequent chronic bronchial infection and exacerbations, and poor prognosis. A causal association has not yet been proven, but it is biologically plausible that COPD, and particularly the infective and exacerbator COPD phenotypes, could be the cause of bronchiectasis without any other known etiology, beyond any mere association or comorbidity.
详细描述
The relationship between bronchiectasis and COPD has generated several questions. Is there any real increased prevalence of bronchiectasis in patients with COPD? Does the presence of bronchiectasis have an impact on the clinical characteristics, prognosis, or response to treatment in COPD, to the extent that it can be considered a distinct clinical phenotype? Should bronchiectasis in patients with COPD be seen as merely a comorbidity, or as a consequence of the disease's natural history? Is there a causal relationship between COPD and bronchiectasis? If this is the case, what are the pathophysiological mechanisms responsible for this relationship? And, finally, what is the role of chronic bronchial infection and exacerbations in this relationship?
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •COPD patients based on GOLD 2019 criteria, stable or in exacerbation
排除标准
- •acute pneumonia within 2 months
- •malignancy
- •congenital bronchiectasis ( immobile cilia syndrome, Kartagnar syndrome).
- •Pregnancy
结局指标
主要结局
Prevalence of Bronchiectasis in COPD
时间窗: 1 year
percentage of bronchiectasis diagnosed by CT chest in COPD patients
次要结局
- impact of bronchiectasis on COPD intensive care admission(1 year)
- impact of bronchiectasis on COPD exacerbations(1 year)
- impact of bronchiectasis on COPD hospitalization(1 year)
研究者
Aliae AR Mohamed Hussein
Professor of Pulmonology
Assiut University