Effects of Dexmedetomidine on Quality of Recovery and Analgesia After Video-assisted Thoracoscopic Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 111
- 试验地点
- 1
- 主要终点
- quality of recovery measured by QoR-40 questionnaire
研究概览
简要总结
Dexmedetomidine is a selective α2 adrenergic agonist that can be considered analgesics, anxiolytic,and anti-stress effect . This randomized, double-blind placebo-controlled trial of intraoperative dexmedetomidine for improvement of quality of recovery and analgesia from surgery. Patients scheduled to undergo video-assisted thoracoscopic surgery (VATS) will be enrolled. Patients will be recruited before the date of their surgery and will complete the Quality of Recovery-40 (QoR-40) questionnaire before their surgery and at 24 and 48 hours post op. They will also complete clinically significant pains score and oxygenation from the postanesthetic recovery unit (PACU).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The inclusion criteria included patients scheduled video-assisted thoracoscopic surgery for lung cancer
- •Adults above 20 years of age and providing informed consent.
- •American Society of Anesthesiologists (ASA) Physical class II, & III patients
排除标准
- •severe functional liver or kidney disease
- •history of chronic pain requiring opioid treatment
- •arrhythmia or received treatment with antiarrythmic drug .
- •severe bradycardia (HR < 45 bpm) and AV block
- •pathologic esophageal lesion (esophageal stricture or varix )
- •psychiatric/central nervous system disturbance that would preclude completion of the QoR-40 questionnaire
- •History of alcohol or drug abuse
研究组 & 干预措施
Dexmedetomidine
干预措施: Dexmedetomidine (Drug)
Saline 0.9%
干预措施: Normal saline (Drug)
结局指标
主要结局
quality of recovery measured by QoR-40 questionnaire
时间窗: 24 hr after operation
pulmonary function test
时间窗: 24 hr after operation
postoperative lung function assessed by spirometry
次要结局
未报告次要终点